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Neurology

Brain and Host Defense

Arnason, B
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Brain and Host Defense

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It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction which serves as an effector response for both the adaptive and innate immune systems. Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus which is also the main director the hormonal regulation of immune/inflammatory. Gender related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioural conditioning (e.g. reward) of immune r

ISBN 9780444535443Edition 01Binding Cloth